As you can see by the expressions on this 500-year-old impression, seasickness is nothing new.

When I look at a picture of a boat, my stomach gets queasy.  So anytime I hear about work being done to enhance the effectiveness of motion-sickness drugs, my stomach gives a gurgle of interest.  Here’s a report, for example, on the development of a trans-dermal patch for the motion-sickness drug domperidone.  Domperidone is attacked by the digestive system so that only about 15% of the medication contained in a pill makes it to the body, so it’s a good candidate for a patch.  But it’s also blocked by the skin.  So it needs to be modified with additions that will help it penetrate the skin.  Of course, with all that modification, the stability needs to be assessed with stability chamber testing.

For further information visit www.ncbi.nlm.nih.gov.

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